• Introduction
• List of disorders involving a loss of hair color (hypopigmentation)

Introduction

The table below records disorders known to involve a lack of pigment (hypopigmentation) in hair fiber. Most of the disorders are piebald traits or subcategories of albinism. This is not necessarily a complete list of disorders involving hair hypopigmentation. There are many more hypopigmentary disorders of the skin that might also involve hair. Links to relevant web pages on the Online Mendelian Inheritance in Man (OMIM) web database are also given where possible.

Where a disorder is known by more than one name, alternative names are given in the second column and the record duplicated in the first column under each respective name. Brackets around alternative disorder names indicate an indirect association, for example a subcategory of the disorder. These records are not duplicated in the first column.

List of disorders involving a loss of hair color (hypopigmentation)

Disorders with hypopigmentation of hair as a symptom	Alternative names for the disorder	Links to OMIM web pages for the disorder (where available)
Acrodermatitis enteropathica	Zinc deficiency	201100
Albinism III	Brown oculocutaneous albinism	203290
Albinism-deafness syndrome	Ziprkowski-Margolis syndrome	300700
Alopecia areata	(Area Celsi, Alopecia totalis, Alopecia universalis)	104000
Ataxia Telangiectasia	Louis-Bar syndrome	208900
Bloch-Sulzberger syndrome	Bloch-Siemens syndrome, Incontinentia pigmenti	308300
Cediak-Hiagashi syndrome	(Albinism)	214500
Cross syndrome	Oculocerebral syndrome with hypopigmentation, Kramer syndrome (Albinism)	257800
Cystathionine-beta-synthase deficiency	Homocystinuria	236200
Franconi anemia		227650
Freeze burn induced hypopigmentation
Grey hair	(Aging)
Griscelli syndrome	(Albinism)	214450
Hermansky-Pudlak syndrome	(Albinism)	203300
Hirschprung disease		142623
Homocystinuria	Cystathionine-beta-synthase deficiency	236200
Incontinentia Pigmenti	Bloch-Sulzberger syndrome, Bloch-Siemens syndrome	308300
Kramer syndrome	Oculocerebral syndrome with hypopigmentation, Cross syndrome (Albinism)	257800
Kwashiorkor
Louis-Bar syndrome	Ataxia telangiectasia	208900
Oculocerebral syndrome with hypopigmentation	Kramer syndrome, Cross syndrome (Albinism)	257800
Osteopathica striata		311280
Phenylalanine hydroxylase deficiency	Phenylketonuria	261600
Phenylketonuria	Phenylalanine hydroxylase deficiency	261600
Piebaldism	(Partial albinism)	172800
Porphyria		176000 176010 176090 176100 176200 263700
Prader-Willi syndrome	(Prader-Labhart-Willi syndrome)	176270
Tietz syndrome		103500
Waardenburg Syndrome	(Waardenburg-Klein syndrome)	193500
Woolf syndrome	(Piebaldism)
Zinc deficiency	Acrodermatitis enteropathica	201100
Ziprkowski-Margolis syndrome	Albinism-deafness syndrome	300700