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What
tissues produce 5 alpha reductase enzymes
There are two types of 5 alpha reductase enzyme each coded by a
separate gene and each produced by different tissues. The diagram
below shows the general tissue distribution of Type I and type II
5 alpha reductase. Although both may be important in pattern baldness
development, type I 5 alpha reductase may be more important because
it is highly active in scalp skin and hair follicle sebaceous glands.
Contrary to popular belief, low levels of type II 5 alpha reductase
have been observed in the outer root sheath of scalp hair follicles.
So local activity of both type I and type II 5 alpha reductase can
contribute to androgenetic alopecia development.
What
tissues produce 5 alpha reductase enzymes references
- Thigpen
AE, Silver RI, Guileyardo JM, Casey ML, McConnell JD, Russell
DW. Tissue distribution and ontogeny of steroid 5 alpha-reductase
isozyme expression. J Clin Invest. 1993 Aug;92(2):903-10.
- Gormley
GJ. Finasteride: a clinical review. Biomed Pharmacother. 1995;49(7-8):319-24.
- Bayne
EK, Flanagan J, Einstein M, Ayala J, Chang B, Azzolina B, Whiting
DA, Mumford RA, Thiboutot D, Singer II, Harris G. Immunohistochemical
localization of types 1 and 2 5alpha-reductase in human scalp.
Br J Dermatol. 1999 Sep;141(3):481-91.
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