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Studies
with 2% minoxidil
There are numerous published studies on the use of 2% topical minoxidil
for patern baldness. The references listed below are by no means
all the studies published. The studies conducted for, and submitted
to, the FDA to gain approval for minoxidil as a pattern baldness
treatment involved counting the number and type of hairs present
witrhin a specified area of scalp skin.
Volunteers in the trials had a small tatoo applied to their scalps
to identify a site for repeated photography throughout the clinical
drug trial. The photos were used to count the number of vellus and
non-vellus hairs. The results showed a significant increase in non-vellus
hair growth and a corresponding reduction in vellus hair numbers
for those using minoxidil. A summary table of the hair counts is
shown below.
after 4 months of
placebo use |
after 4 months of
Rogaine use |
after 12 months of
Rogaine use |
New hairs
= 39
(p<.0005) |
New hairs
= 72
(p<.0005) |
New hairs
= 112
(p<.0005) |
Similar studies were conducted on women as shown.
after 8 months
of placebo use |
after 8 months
of Rogaine use |
|
New hairs = 11.0
(p<.0004)
|
New hairs = 22.7
(p<.0004)
|
As well as conducting hair counts the studies also involved taking
photogrpahs of the scalp. These photos were then evaluated for degrees
of hair growth by comparing the photos taken during the study with
photos taken before the study started. There were four categories
for for hair regrowth.
1. None: No visible regrowth.
2. Minimal: Barely discernible regrowth.
3. Moderate: Readily discernible regrowth.
4. Dense: Full regrowth similar to non-thinning areas.
| after 4 months of placebo use |
after 4 months of Rogaine use |
after 12 months of Rogaine use |
| None = 68% |
None = 42% |
None = 16% |
| Minimal = 31% |
Minimal = 32% |
Minimal = 36% |
| Moderate = 9% |
Moderate = 24% |
Moderate = 40% |
| Dense = 2% |
Dense = 2% |
Dense = 8% |
| Total = 100% |
Total = 100% |
Total = 100%
(p<.0005) |
Clinical studies at 27 US medical centers involving over 2,300
patients concluded that minoxidil increases hair growth in both
men and women.
Studies
with 2% minoxidil references
- DeVillez
RL, Jacobs JP, Szpunar CA, Warner ML. Androgenetic alopecia in
the female. Treatment with 2% topical minoxidil solution. Arch
Dermatol. 1994 Mar;130(3):303-7.
- Whiting
DA, Jacobson C. Treatment of female androgenetic alopecia with
minoxidil 2%. Int J Dermatol. 1992 Nov;31(11):800-4.
- Olsen
EA. Topical minoxidil in the treatment of androgenetic alopecia
in women. Cutis. 1991 Sep;48(3):243-8.
- Kuan
YZ, Chen SY, Chen MJ, Wang CN, Chan HL. Safety and efficacy of
2% topical minoxidil in the management of male pattern baldness
in Chinese. Chang Keng I Hsueh Tsa Chih. 1990 Jun 20;13(2):96-103.
- Olsen
EA, Weiner MS, Amara IA, DeLong ER. Five-year follow-up of men
with androgenetic alopecia treated with topical minoxidil. J Am
Acad Dermatol. 1990 Apr;22(4):643-6.
- Connors
TJ, Cooke DE, De Launey WE, Downie M, Knudsen RG, Shumack S, Eggleston
AS. Australian trial of topical minoxidil and placebo in early
male pattern baldness. Australas J Dermatol. 1990;31(1):17-25.
- Rushton
DH, Unger WP, Cotterill PC, Kingsley P, James KC. Quantitative
assessment of 2% topical minoxidil in the treatment of male pattern
baldness. Clin Exp Dermatol. 1989 Jan;14(1):40-6.
- Koperski
JA, Orenberg EK, Wilkinson DI. Topical minoxidil therapy for androgenetic
alopecia. A 30-month study. Arch Dermatol. 1987 Nov;123(11):1483-7.
- Katz
HI, Hien NT, Prawer SE, Goldman SJ. Long-term efficacy of topical
minoxidil in male pattern baldness. J Am Acad Dermatol. 1987 Mar;16(3
Pt 2):711-8.
- Roberts
JL. Androgenetic alopecia: treatment results with topical minoxidil.
J Am Acad Dermatol. 1987 Mar;16(3 Pt 2):705-10.
- Savin
RC. Use of topical minoxidil in the treatment of male pattern
baldness. J Am Acad Dermatol. 1987 Mar;16(3 Pt 2):696-704.
- Olsen
EA, DeLong ER, Weiner MS. Long-term follow-up of men with male
pattern baldness treated with topical minoxidil. J Am Acad Dermatol.
1987 Mar;16(3 Pt 2):688-95.
- Rietschel
RL, Duncan SH. Safety and efficacy of topical minoxidil in the
management of androgenetic alopecia. J Am Acad Dermatol. 1987
Mar;16(3 Pt 2):677-85.
- Shupack
JL, Kassimir JJ, Thirumoorthy T, Reed ML, Jondreau L. Dose-response
study of topical minoxidil in male pattern alopecia. J Am Acad
Dermatol. 1987 Mar;16(3 Pt 2):673-6.
- Spindler JR. The safety of topical minoxidil
solution in the treatment of pattern baldness: the results of
a 27-center trial. Clin Dermatol. 1988 Oct-Dec;6(4):200-12.
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