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- Alopecia
areata - overview. A general overview of alopecia areata
and what it is.
- Alopecia
areata - history. A brief history of alopecia areata
to the present day.
- Alopecia
areata - initiating factors. Some comments on potential trigger
factors and mechanisms in alopecia areata.
- Alopecia
areata - diagnosis. An introduction to the diagnosis of alopecia
areata.
- Alopecia
areata - clinical presentation. The clinical presentation
of alopecia areata.
- Alopecia
areata - histopathology. The histopathology of alopecia areata.
- Alopecia
areata - autoimmune disease pathogenesis. An explanation of
autoimmunity in alopecia areata, why hair follicles are not destroyed.
- Alopecia
areata - epidemiology and genetics. Commentary on alopecia
areata epidemiology.
- Alopecia
areata - epidemiology and clinical disease patterns.
The clinical presentation of alopecia areata is quite variable,
but some studies have suggested patterns that can be used
to predict the nature of the disease and its response to
treatment.
- Alopecia
areata - genetics. The genetics behind alopecia areata
are complex.
- Alopecia
areata - autoantibodies.
Autoimmune diseases may involve production of self reactive
antibodies. Here is an explanation of autoantibodies in alopecia
areata.
- Alopecia
areata - nail changes in alopecia areata. Finger and
toe nails are modified hair follicles. In the same way that
hair follicles can be targeted in alopecia areata, nails
can also be affected. Not all people with alopecia areata
see changes in their nails, but many do.
- Alopecia
areata - alternative pathogenesis hypothesis. Some dermatologists
do not believe autoimmunity is the primary driving force behind
alopecia areata.
- Alopecia
areata - introduction to treatments. A brief review of the
treatment options for alopecia areata.
- Alopecia
areata - treatment with corticosteroids overview. Topical,
intralesional, and systemic treatment using corticosteroid
drugs is the most
common treatment approach in dermatology clinics.
- Alopecia
areata - treatment with topical corticosteroids . Topical,corticosteroids
are a common treatment approach for alopecia
areata present as just one or two patches.
- Alopecia
areata - treatment with intralesional corticosteroids .
Intralesional corticosteroid treatment involves injections
of drugs into the alopecia patches. It is a treatment approach
that is effective for those with multiple patches of alopecia
areata.
- Alopecia
areata - treatment with systemic corticosteroids .
Systemic treatment using corticosteroid
drugs is a significant undertaking, but it can work well
for some people with extensive alopecia areata.
- Alopecia
areata - treatment with irritants and sensitizers overview.
People with extensive alopecia areata can be treated with
chemicals that
irritate the skin and stimulate the immune system.
- Alopecia
areata - treatment with diphenylcyclopropenone (DCP).
DCP is a contact sensitizing chemical used in Europe and
Canada to treat extensive alopecia
areata. Studies suggest it works quite well.
- Alopecia
areata - treatment with squaric acid dibutylester (SADBE).
SADBE is a contact sensitizing chemical used in some clinics
to treat extensive alopecia areata. Studies suggest it works
quite
well though in Europe and Canada DCP is tried first and
if that fails then dermatologists use SADBE.
- Alopecia
areata - treatment with irritants.
Irritant chemicals have been used for thousands of years
to treat alopecia areata. Most irritant treatments are no
longer used, but anthralin and nitrogen mustard are
available in some clinics.
- Alopecia areata - treatment with PUVA.
Psoralen plus and ultraviolet A radiation (PUVA) is a
treatment for alopecia areata that involves sensitizing inflammatory cells in
the skin and destroying them with ultra violet light.
- Alopecia
areata - treatment with UVB light. Ultra violet B light has
been used in a few studies to treat alopecia areata with some
success.
- Alopecia
areata - topical immunomodulating drugs. Some selective
immunomodulating drugs have been suggested as potential
treatments for alopecia areata. Tacrolimus, pimecrolimus,
and cyclosporin are being considered.
- Alopecia
areata - minoxidil treatment. Minoxidil is a direct
hair growth promoting drug that has been used to treat alopecia
areata.
While some claim it is helpful other dermatologists have
found minoxidil to be of less use.
- Alopecia areata
- combination treatments. Sometimes if one treatment
approach is not successful it may be used in combination
with a different type of treatment. Here is a run
down on the research that has been conducted on using a
combination of more than one treatment for alopecia areata.
- Alopecia
areata - biologic drugs. Biologic agents are under development
for the treatment of several autoimmune diseases. These
special drugs are modified proteins that selectively interfere
with specific components of the immune system. Some of these
drugs may have potential for treating alopecia areata.
- Alopecia
areata - desensitization and oral tolerance. There are
several experimental treatments being developed for other
autoimmune diseases that may be adapted for use in treating
alopecia areata. Desensitization and oral tolerance are
two approaches that have been suggested.
- Alopecia
areata - treatment with alternative therapies. Individuals
may prefer to treat their alopecia areata with alternative techniques.
- Alopecia
areata - hypothetical treatment approaches.
If alopecia areata is an autoimmune disease, there are several
points in the disease mechanism which might be targeted
with the development of new treatments.
- Alopecia
areata - common questions I. Questions and answers about
who is affected, when onset is most liekly to occur, and
the risk of inheritance in children.
- Alopecia
areata - common questions II. Questions and answers
about alopecia areata and sweating, human evolution, and
the future of alopecia areata research.
- Alopecia
areata - common questions III. Questions and answers
about the potential for spontaneous regrowth and does alopecia
areata occur in patterns.
- Alopecia
areata - association with other autoimmune diseases.
Alopecia areata is beleived to be an autoimmune disease
partly because people who have alopecia areata are also
more likely to have other autoimmune diseases. Here is a
review of the other autoimmune diseases found in association
with alopecia areata.
- Alopecia
areata - association with other diseases. Some people
have alopecia areata in association with other diseases
and disorders. This page reviews some of the associations
found so far.
- Alopecia
areata - reference tables. A reference table list on
alopecia areata prevalence in families, age of onset bias,
and more.
- Alopecia
areata - antigen targets in alopecia areata. There are
several possible structures that immune cells might target
in the pathogenesis of alopecia areata. This page provides
a short review.
- Alopecia
areata - immunobiology of hair follicles in alopecia areata.
Hair follicles are believed to have immune privilege. The loss
of this immune privilege may be one posible expalanation
as to why aloepcia areata develops.
- Alopecia
areata - evidence of an autoimmune etiology in alopecia
areata.
Most scientists and dermatologsts believe that alopecia
areata is an autoimmune disease. This page reviews the supporting
evidence for this claim.
- Alopecia
areata - animals with alopecia areata. It's not just
humans that get alopecia areata, any animal with hair can
get this disease.
- Alopecia
areata - different types, sub terms and synonyms. Alopecia
areata can present in many different forms including alopecia
totalis, alopecia universalis, alopecia ophiasis and several
others. Also included is a list of sub terms and synonyms
for alopecia areata.
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- Alopecia
areata books. Reviews and links to the online internet bookstore
Amazon.com for books about alopecia areata.
- Wigs/Cover
Ups. Links to web sites and companies that sell wigs, eyelashes,
eyebrows, hats, turbans and other supplies for people with extensive
hair loss.
- Immunology.
Many hair loss diseases involve inflammation and this section
provides background information. Some pages in this section was
written with alopecia areata in mind.
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