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Cancer
induced hypertrichosis
Hypertrichosis can sometimes be promoted by malignant tumors.
Sometimes internal cancers will promote systemic hypertrichosis
but more frequently localized hypertrichosis can be observed in
the skin immediately above a tumor. Usually the hair produced is
unpigmented lanugo hair and so cancer induced hypertrichosis is
often described as "acquired hypertrichosis lanuginosa".
In some instances cancer induced hypertrichosis has been called
"malignant down".
How cancers promote hair growth is not known, but most likely the
rapidly proliferating tumor cells are producing many cytokine chemical
signals that promote cell growth. This promotes the development
of the tumor but can also promote other proliferating cells. The
hair follicles are the most active proliferating, non-cancerous
cells in the body and so they may be affected by the stimulatory
cytokines. In addition, many tumors promote angiogenesis, that is
the infiltration of the tumor by blood vessels. This increases nutrient
supply to the tumor. Any adjacent normal skin tissue may also benefit
from the increased blood supply and increased hair follicle activity
may be the result.
Cancer
induced hypertrichosis references
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