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Ketoconazole
for hirsutism
Ketoconazole is a relatively new and particularly potent anti androgen
drug. Since 1985 there have been various studies suggesting that
ketoconazole could be used to treat hirsutism. Ketoconazole works
by blocking the production of hormones by the ovaries and the adrenal
glands.
As with other antiandrogen drugs, there are several different research
reports that claim a reduction in hirsutism with different drug
use protocols. The intake of ketoconazole may range from 200mg to
400mg a day.
Although the list of references below might seem to suggest that
ketoconazole is a popular treatment for hirsutism, most dermatologists
are wary of using it on a regular basis. Because it is such a powerful
anti androgen, some dermatologists believe the risk of side effects
is greater than with other antiandrogen drugs. Dermatologists are
particularly concerned with the risk of hepatotoxicity when using
ketoconazole. Most dermatologists only use ketoconazole when the
hirsutism is particularly pronounced and even then the drug is only
prescribed for a brief period of time before switching to other
antiandrogen drugs.
Ketoconazole
for hirsutism references
- Venturoli
S, Marescalchi O, Colombo FM, Macrelli S, Ravaioli B, Bagnoli
A, Paradisi R, Flamigni C. A prospective randomized trial comparing
low dose flutamide, finasteride, ketoconazole, and cyproterone
acetate-estrogen regimens in the treatment of hirsutism. J Clin
Endocrinol Metab. 1999 Apr;84(4):1304-10.
- Isik AZ,
Gokmen O, Zeyneloglu HB, Senoz S, Zorlu CG. Low dose ketoconazole
is an effective and a relatively safe alternative in the treatment
of hirsutism. Aust N Z J Obstet Gynaecol. 1996 Nov;36(4):487-9.
- Vidal-Puig
AJ, Munoz-Torres M, Jodar-Gimeno E, Garcia-Calvente CJ, Lardelli
P, Ruiz-Requena ME, Escobar-Jimenez F. Ketoconazole therapy: hormonal
and clinical effects in non-tumoral hyperandrogenism. Eur J Endocrinol.
1994 Apr;130(4):333-8.
- Akalin
S. Effects of ketoconazole in hirsute women. Acta Endocrinol (Copenh).
1991 Jan;124(1):19-22.
- Conget
JI, Halperin I, Ferrer J, Gonzalez-Clemente JM, Martinez-Osaba
MJ, Vilardell E. Evaluation of clinical and hormonal effects in
hirsute women treated with ketoconazole. J Endocrinol Invest.
1990 Dec;13(11):867-70.
- Venturoli
S, Fabbri R, Dal Prato L, Mantovani B, Capelli M, Magrini O, Flamigni
C. Ketoconazole therapy for women with acne and/or hirsutism.
J Clin Endocrinol Metab. 1990 Aug;71(2):335-9.
- Cedeno
J, Mendoza SG, Velazquez E, Nucete H, Speirs J, Glueck CJ. Effect
of ketoconazole on plasma sex hormones, lipids, lipoproteins,
and apolipoproteins in hyperandrogenic women. Metabolism. 1990
May;39(5):511-7.
- Sonino
N, Scaroni C, Biason A, Boscaro M, Mantero F. Low-dose ketoconazole
treatment in hirsute women. J Endocrinol Invest. 1990 Jan;13(1):35-40.
- Weber MM,
Luppa P, Engelhardt D. Inhibition of human adrenal androgen secretion
by ketoconazole. Klin Wochenschr. 1989 Jul 17;67(14):707-12.
- Martikainen
H, Heikkinen J, Ruokonen A, Kauppila A. Hormonal and clinical
effects of ketoconazole in hirsute women. J Clin Endocrinol Metab.
1988 May;66(5):987-91.
- Or M, Akbatur H, Hasanerisoglu B, Bilgihan
K, Cakir N. Ketoconazole induced papilledema. Acta Ophthalmol
(Copenh). 1993 Apr;71(2):270-2.
- Sonino N. Current trends in the endocrine
use of ketoconazole. J Endocrinol Invest. 1988 Nov;11(10):741-4.
- De Pedrini P, Tommaselli A, Spano G, Montemurro
G. Clinical and hormonal effects of ketoconazole on hirsutism
in women. Int J Tissue React. 1988;10(3):193-8.
- Sonino N. The endocrine effects of ketoconazole.
J Endocrinol Invest. 1986 Aug;9(4):341-7.
- Carvalho D, Pignatelli D, Resende C. Ketoconazole
for hirsutism. Lancet. 1985 Sep 7;2(8454):560.
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