Poliosis
Poliosis is the name given to a localized patch of white hair.
Most frequently, poliosis presents as a white forelock, but it can
involve a patch of white hair in normally pigmented hair anywhere
on the body. Poliosis can occur in otherwise healthy people and
may represent no more than an anomaly of hair and skin pigmentation.
However, poliosis is also observed in association with a wide variety
of conditions. At the mild end of the spectrum, a minor genetic
defect called piebaldism results in poliosis. Somewhat more significant,
poliosis may be associated with pigmentary disturbances of the eye,
as well as hair loss in hypogonadism and thyroid diseases.
Localized changes in the skin may also cause poliosis. Nevi and
various kinds and focal skin cancers may result in patches of white
hair growth in the areas of affected skin.
At the other end of the disease and disorder spectrum where poliosis
can be found, several genetic disorders involve poliosis such as
Marfan's syndrome, Vogt-Koyanagi-Harada (VKH) syndrome, and Waardenburg's
syndrome. These syndromes involve other physical symptoms and mental
retardation to varying degrees.
Poliosis
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