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Syndrome
induced premature gray hair development
There are some syndromes with which early onset of gray hair has
been associated. Those that are serious, such as progeria type syndromes,
become apparent at any time from birth to puberty. Gray hair can
be one of the visible symptoms, particularly in Werner's syndrome,
but much more serious symptoms are usually noticed first. These
syndromes involve accelerated aging of the individual and children
with these conditions have reduced life spans. Other syndromes with
a serious impact on health that can occasionally involve premature
gray hair development include Rothmund-Thomson syndrome and chromosome
5 syndrome (Cri du Chat syndrome).
An autosomal dominant genetic syndrome called Böök's
syndrome involves premature graying along with tooth development
problems (teeth are very similar structures to hair follicles).
Palmoplantar hyperhidrosis (sweaty hands and feet) is another symptom
of Böök's syndrome. It is a condition that runs in families
with individuals affected to differing degrees.
Premature gray hair has also been associated with dyslexia in at
least one study. What mechanism might be involved is entirely unknown,
but hair follicles are responsive to neuroendocrine peptides produced
by nerve cells and hair follicles are intimately enmeshed in a complex
nerve cell network. Perhaps dyslexia is associated with a reduced
ability of nerve cells to produce certain stimulatory products that
may also affect hair follicle activity?
In addition to these syndromes inducing premature gray hair, disease
may also promote hair color changes including gray hair. See; hair
color changes secondary to disease for details.
Syndrome
induced premature gray hair development references
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Nondextrality and autoimmune disorders among relatives of language-disabled
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twenty-four cases with a review of the Japanese medical literature.
J Am Geriatr Soc. 1982 May;30(5):303-8.
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of hypodontia. I. Premolar aplasia, hyperhidrosis, and canities
prematura. A new hereditary syndrome in man. Am J Hum Genet. 1950;
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