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kerion

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Kerion

A kerion is not an infectious agent in itself rather a kerion is the skin leison that develops when an infectious agent that normally causes scalp ringworm (tinea capitis) becomes more aggressive. Deep boggy red areas characterized by a severe acute inflammatory infiltrate with pustule formation are termed kerions or kerion celsi. Normally, scalp ringworm inducing agents cause circular patches of red crusty skin. Although not pleasant, the problem is relatively mild and reversible with proper treatment. However, if the infection gets out of hand a kerion may develop.


Kerion clinical features

When a kerion develops it first starts out as a more typical presentation of tinea capitis with a flaky, crusty patch of skin on the scalp. This can quickly deteriorate into a boggy, puritic mass of inflamed tissue. This is a kerion. The kerion can deteriorate to a nasty, deep abscess if it is not treated correctly. This has the potential to to elicit scarring and permanent alopecia. When a kerion develops with severe inflammation it is fairly common for the regional lymph nodes in the neck to become enlarged (called cervical lymphadenopathy). Suppuration and kerion formation are more commonly are typically associated with Trichophyton tonsurans infection. Kerion formation with other infectious agents that cause tinea capitis are less likely, but still possible.


Kerion differential diagnosis

Sometimes Kerion Celsi is confused with other conditions due to a lack of diagnostic testing. In one report, some patients were hospitalized with the diagnosis of Staphylococcal abscess while a microbiological diagnostic test would have shown the cause was due to Trichophyton verrucosum infection resulting in a kerion (Zaror, 1995). Occasionally, a kerion can look much like some forms of scarring alopecia such as dissecting cellulitis or erosive pustular dermatosis. Because of this apparent similarity in presentation, the doctor needs to be very careful in their investigation and knowledgeable about the potential for confusing kerions with other diagnoses. The patient who suspects they have a kerion caused by an infectious agent or something similar needs to find an experienced dermatologist to improve the chances of getting a correct diagnosis. The average general practitioner is probably not in a position to make a kerion diagnosis with confidence.


Kerion treatment

Early initiation of treatment is extremely important with kerions. The sooner treatment is started the less likely the kerion will promote a permanent scarring alopecia. Unfortunately, some reports suggest that rapid diagnosis and treatment of kerions only occurs in a minority of cases or that kerions are often misdiagnosed. There seems to be a certain lack of knowledge about tinea capitis and kerions among some general practitioners and this can lead to a delay in receiving proper treatment. The longer kerions persist the more damaging they become. When a kerion is diagnosed, the typical immediate treatment response is a course of "Griseofulvin", an anti fungal agent. Most patients with kerions and a primary diagnosis of tinea capitis also have a secondary bacterial infection of the kerion. Griseofulvin is not good for treating bacterial or yeast infections so other anti-bacterial treatments may be given along with the Griseofulvin. Some published case reports have indicated the newer anti fungal agents Itraconazole and Terbinafine have also been successfully used to treat kerions. Sometimes oral corticosteroids are also given in addition to the anti fungal agent, although the few published studies comparing treatments with and without corticosteroids have shown little added benefit. However in principle, oral corticosteroids should help reduce the inflammation in the kerion. Topical corticosteroids are not used as this can complicate the local fungal infection.


Kerion references

  • Tanuma H, Doi M, Abe M, Kume H, Nishiyama S, Katsuoka K. Case report. Kerion Celsi effectively treated with terbinafine. Characteristics of kerion Celsi in the elderly in Japan. Mycoses. 1999;42(9-10):581-5.
  • Aste N, Pau M, Biggio P. Kerion Celsi: a clinical epidemiological study. Mycoses. 1998 Mar-Apr;41(3-4):169-73.
  • Pomeranz AJ, Fairley JA. Management errors leading to unnecessary hospitalization for kerion. Pediatrics. 1994 Jun;93(6 Pt 1):986-8.
  • Ginsburg CM, Gan VN, Petruska M. Randomized controlled trial of intralesional corticosteroid and griseofulvin vs. griseofulvin alone for treatment of kerion. Pediatr Infect Dis J. 1987 Dec;6(12):1084-7.
  • Calista D, Schianchi S, Morri M. Erythema nodosum induced by kerion celsi of the scalp. Pediatr Dermatol. 2001 Mar-Apr;18(2):114-6.
  • Kobayashi M, Yamamoto O, Suenaga Y, Asahi M. Kerion celsi in an infant treated with oral terbinafine. J Dermatol. 2001 Feb;28(2):108-9.
  • Ive FA. Kerion formation caused by Trichophyton rubrum. Br J Dermatol. 2000 May;142(5):1065-6.
  • Hussain I, Muzaffar F, Rashid T, Ahmad TJ, Jahangir M, Haroon TS. A randomized, comparative trial of treatment of kerion celsi with griseofulvin plus oral prednisolone vs. griseofulvin alone. Med Mycol. 1999 Apr;37(2):97-9.
  • Beswick SJ, Das S, Lawrence CM, Tan BB. Kerion formation due to Trichophyton rubrum. Br J Dermatol. 1999 Nov;141(5):953-4.
  • Jury CS, Lucke TW, Bilsland D. Trichophyton erinacei: an unusual cause of kerion. Br J Dermatol. 1999 Sep;141(3):606-7.
  • Hussain I, Muzaffar F, Rashid T, Ahmad TJ, Jahangir M, Haroon TS. A randomized, comparative trial of treatment of kerion celsi with griseofulvin plus oral prednisolone vs. griseofulvin alone. Med Mycol. 1999 Apr;37(2):97-9.
  • Gupta G, Burden AD, Roberts DT. Acute suppurative ringworm (kerion) caused by Trichophyton rubrum. Br J Dermatol. 1999 Feb;140(2):369-70.
  • Aste N, Pau M, Biggio P. Trichophyton mentagrophytes kerion in a woman. Br J Dermatol. 1996 Dec;135(6):1010-1.
  • Zaror L, Hering M, Moreno MI, Navarrete M. [Kerion Celsi. A diagnostic problem? Experience with 6 cases] Rev Med Chil. 1995 Aug;123(8):1006-8.
  • Gordon PM, Stankler L. Rapid clearing of kerion ringworm with terbinafine. Br J Dermatol. 1993 Oct;129(4):503-4.
  • Honig PJ, Caputo GL, Leyden JJ, McGinley K, Selbst SM, McGravey AR. Microbiology of kerions. J Pediatr. 1993 Sep;123(3):422-4.
  • Gatti S, Marinaro C, Bianchi L, Nini G. Treatment of kerion with fluconazole. Lancet. 1991 Nov 2;338(8775):1156.
  • McDonagh AJ, Bleehen SS.Kerion masquerading as erosive pustular dermatosis of the scalp. Br J Dermatol. 1991 May;124(5):507-8.
  • Sperling LC. Inflammatory tinea capitis (kerion) mimicking dissecting cellulitis. Occurrence in two adolescents. Int J Dermatol. 1991 Mar;30(3):190-2.
  • Franks AG, Rosenbaum EM, Mandel EH. Trichophyton sulfureum causing erythema nodosum and multiple kerion formation. Arch Dermatol Syphil 1952;65:95-97.

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